Having said that, a 2007 review of clinical trials on milk thistle , while not deeply investigative of the benefits of milk thistle, did conclude that milk thistle extracts were known to be safe and well tolerated, and that toxic or adverse effects observed in the reviewed clinical trials were minimal. Gastrointestinal issues 2. Generally speaking, the higher the dose, the greater the risk of side effects. ” Are They Good For You? Some drugs like Tamoxifen (which is also a popular drug in bodybuilding) act directly on estrogen receptors thus may block the estrogenic effects of silymarin (which is an Estrogen receptor Beta agonist). A 14 days treatment with Silymarin BIO-C at dosages of 25 mg/kg and 200 mg/kg administered orally dose dependently increased the serum prolactin levels. There is simply a misguided warning. That is a scary warning, but is it valid? deferscript("https://z-na.amazon-adsystem.com/widgets/onejs?MarketPlace=US&adInstanceId=757dd97e-a520-475d-bf12-560fedea8cae",false,1,false); Copyright © 2011 - 2020 Incnut Digital. Much of that increase is related to the costs of drugs. 2001 Sep;22(9):1399-403. Sure, this may seem like a really high dosage but whole Milk Thistle seeds are harder to assimilate than extract in capsules which is highly processed to make it bioavailable. Supplements containing extracts of the silymarin-phosphatidylcholine compound are generally limited to 200 to 400 milligrams a day, while herbal tinctures and liquid extracts of milk thistle often include recommended dosages on their labels according to the level of dilution. Methods Mol Biol. Women orally treated for 63 days with Silymarin showed a clear galactagogue role for the product with an increase of 85.94% of the daily milk production (placebo: +32.09%). Ramasamy K, Agarwal R. Multitargeted therapy of cancer by silymarin. You can also “like” me on Facebook (Marnie Clark, Breast Health Coach) to get my inspirational snippets, news and updates. Wikiversity Journal of Medicine 1 (1). Can Interact With Cholesterol Medication 5. May Have Interactions During Breastfeeding And Pregnancy, 5. Silymarin protects the liver by: • Acting as a direct antioxidant and free radical scavenger. ” . Milk thistle components have been shown to exert dual effects on bone health by preventing the breakdown of bone by cells known as osteoclasts while at the same time improving the building of bone by osteoblasts. Interactions Milk thistle may interfere with the effects of estrogen replacement therapy and oral contraceptives due to its possible estrogenic effects. Clinical efficacy, safety and tolerability of BIO-C (micronized Silymarin) as a galactagogue. Even though silymarin may have a positive effect on prostate cancer cells, the effects of silymarin administration to healthy male may have the negative effects. I also wanted to thank you for being with me during my treatments. Milk production in the cows of control groups was decreasing during the trial (up to P 0.01), but in the test cows it was higher by 7.7% (trial 1) and by 3.4% (trial 2), in comparison with the milk yield at the beginning of the trials. “Reference ranges for estradiol, progesterone, luteinizing hormone and follicle-stimulating hormone during the menstrual cycle”. Phytosomes are a combination of silymarin with phosphatidylcholine molecules to aid their absorption. “Thank you for the email and the meaningful words. YES – that means phytoestrogens are protective for both breast and uterine tissues. 1) Forinash AB, Yancey AM, Barnes KN, Myles TD. “Silymarin”, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. An updated systematic review with meta-analysis for the clinical evidence of silymarin. serving. The statistics on the growing epidemic of type 2 diabetes are staggering as it is now estimated that over 100 million Americans have diabetes or prediabetes and are at high risk of developing diabetes. Might Interact With Other Drugs 8. epigenetic factors to reduce breast cancer. In one case, milk thistle had caused excessive sweating and weakness (14). [10,11] Tamoxifen (brand name Nolvadex) is the drug which is a selective estrogen-receptor modulator and inhibits also the aromatase enzyme which is responsible for conversion of … As it relates to milk thistle extract (silymarin), there are warnings out in the marketplace that women avoid milk thistle extract as it increases the risk of breast cancer and has estrogenic effects. Sure, the customers want something they get to know, then they buy something and use something. And a 2013 review of medical studies  on milk thistle found that silymarin played a crucial role in helping to prevent bone loss. A 2015 preclinical study  found that silibinin inhibited a gene known as STAT3 which known to be involved in cancer tumor growth and spread (metastasis). Med-Czech 46, 2001 (1): 17-23” width=”694″ height=”182″ /> Always consult with a qualified healthcare professional prior to beginning any diet or exercise program or taking any dietary supplement. Some bodybuilders abusing the anabolic steroids have their breast glands removed in order to avoid the gynecomastia. I am talking about the soy lecithin which is actually a highly concentrated extract of some beneficial nutrients found in soy. How this happens is yet to be studied. Like any hormone, testosterone has some negative side effects. [10,11] Tamoxifen (brand name Nolvadex) is the drug which is a selective estrogen-receptor modulator and inhibits also the aromatase enzyme which is responsible for conversion of … The potency and clinical efficacy of aromatase inhibitors across the breast cancer continuum.