Number of times cited according to CrossRef: Bioinspired structural color particles with multi-layer graphene oxide encapsulated nanoparticle components. 1992). Eye-on-a-chip (EOC) models and their role in the future of ophthalmic drug discovery. Any queries (other than missing content) should be directed to the corresponding author for the article. 2011). In this scenario, droplet formation will be determined by the saccade parameters, the ratio of the fluid viscosities, and factors affecting contact line motion including the topology of the surface and species secreted by the cells on the retina wall. No droplets were formed at the bulk SiOil‐aqueous interface. and you may need to create a new Wiley Online Library account. It can wait for few weeks. Together with the properties of ease of injection and removal, SiO with HMW should be a more preferred candidate than conventional SiO as the tamponade. Development of emulsification‐resistant silicone oils: can we go beyond 2000 mPas silicone oil? 1962; Kanski & Daniel. 2004; Chan et al. Figure 2c shows the simulated velocity profiles for a single‐phase fluid in a spherical chamber at five sample times. The filled RBF was attached to a stepper motor, as shown in Fig. When used inside an eye, it remains unclear how increasing extensional viscosity of SiO might reduce emulsification. Care was taken to avoid air bubbles in either phase or unwanted mixing. 2015) to support emulsification, but bulk emulsification was not observed here with an oil of low viscosity (500 mPas). It can wait for few weeks. You are right this is silicone oil emulsification at the top of your eye. Intraocular silicone oil has several important indications in vitreoretinal surgery, particularly the repair of complicated retinal detachments. Blood components such as red blood cell ghosts, plasma, and lymphocytes have been shown to have significant effects in experimental models of silicone oil emulsification (Bartov et al. They studied two sets of saccadic motion (A = 9°, ω = 390°/s, D = 50 ms and A = 90°, ω = 360°/s, D = 300 ms) and did not report droplet formation in either case. Such a short experimental period may not be enough to induce adequate amount of emulsified SiO droplets to compare viscous SiO, such as SiOHMW5000 with its counterparts. For a given saccadic motion, Fig. The square wave was expressed as a Fourier series, and the solution to the governing equations was obtained by combining the response to each component of the Fourier series. 90 vol%) were investigated. //-->. Moreover, we cannot provide the full quantification of size or of number distribution of the emulsified droplets in each group because some emulsified droplets are too small to be seen by optical microscopy (Chan et al. I think the silicone oil in my eye has emulsified as there’s a strange liquid at the top of my eye, furthermore when looking downwards my vision becomes foggy. From our tests in the cell‐lined eye‐on‐a‐chip model, the use of the HMW additives generally reduces the emulsified droplets. vortex, orifice homogenizers and sonication) (Nakamura, Refojo & Crabtree 1990; Caramoy et al. Silicone oil (SiO) filaments are observed during the movement of SiO with adhesion onto the cellular substrate.