Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, et al. Learn more about getting a second opinion before starting treatment, so you are comfortable with your treatment plan chosen. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Semin Oncol. This treatment is generally used as a temporary treatment until a person receives treatment with medication (see below), which provides control of IgM proteins over a longer time. Clin Lymphoma Myeloma. Leuk Res. The Mayo Clinic Health System has dozens of locations in several states. The health care team has special skills, experience, and knowledge to support patients and their families and is there to help. 1-9. Learn more about coping with the fear of recurrence. Prognostic factors and response to fludarabine therapy in patients with Waldenstrom macroglobulinemia: results of United States intergroup trial (Southwest Oncology Group S9003). Some insurers require referrals, or may have additional requirements for certain medical care. 30 (2):110-5. [Medline]. [Medline]. Healthline Media does not provide medical advice, diagnosis, or treatment. . Side effects include low blood counts, nausea, and pain and numbness in the feet and legs due to nerve damage. [Medline]. The blood cells are then mixed with a plasma substitute, usually an albumin solution, and returned to the patient. A monoclonal antibody is a type of targeted therapy. Temporal and geographic variations of Waldenstrom macroglobulinemia incidence: A large population-based study. © 2005-2020 American Society of Clinical Oncology (ASCO). A revised international prognostic score system for Waldenström's macroglobulinemia. 1219134-overview The medications used to treat cancer are continually being evaluated. Very rarely, the recurrence may come as a different type of lymphoma, usually diffuse large B-cell lymphoma (DLBCL). During a stem cell transplant, diseased bone marrow is replaced with healthy blood stem cells. 2009 Aug. 55(8):1517-22. In: Hematology: Basic Principles and Practice. Available at https://ghr.nlm.nih.gov/gene/MYD88#conditions. They’re often used to treat multiple myeloma, but doctors sometimes prescribe them to people with WM, too. Caers J, Vekemans MC, Bries G, Beel K, Delrieu V, et al. [Medline]. They are effective therapy for patients who are primarily resistant or who relapse after alkylating agents. See our safe care and visitor guidelines, plus trusted coronavirus information. Ghobrial IM, Gertz M, Laplant B, et al. Available at https://wayback.archive-it.org/7993/20170723002608/https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm432123.htm. If you’re getting a bone marrow (stem cell) transplant, you may receive high-dose chemotherapy first. Treatment options and recommendations depend on several factors, including the type and stage of cancer, possible side effects, and the patient’s preferences and overall health. Gavriatopoulou M, García-Sanz R, Kastritis E, Morel P, Kyrtsonis MC, Michalis E, et al. There's no cure for Waldenstrom's macroglobulinemia, but there are treatments that can help. Dhodapkar et al, in a study evaluating fludarabine response in previously untreated and previously treated patients, reported an overall response rate of 36%, with 3% of patients experiencing complete remission; the overall survival period was 84 months. Your care team will work closely with you to understand your needs and goals and to develop a personalized treatment plan. Ibrutinib in previously treated Waldenström's macroglobulinemia. Thomas R, Braschi-Amirfarzan M, Laferriere SL, Jagannathan JP. The diagnosis of WM requires a bone marrow (BM) biopsy showing infiltration by clonal lymphoplasmacytic cells/lymphoplasmacytic lymphoma (LPL) and the presence of any amount of … A Waldenstrom macroglobulinemia expert shares information on treatment and prognosis for Waldenstrom macroglobulinemia, as well as advice for patients.